Meeting Program 2018-04-03T12:56:48+00:00

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Final Program

All meetings will be held in the Grand Ballroom 1-2. Coffee breaks and poster socials will be held in Grand Ballroom 3.

High-Throughput Screening and Ecological Risk Assessment – Background and Setting the Stage

Time Title Speakers
7:45 a.m.–8:30 a.m. Registration in the Ballroom Foyer
8:30 a.m.–8:35 a.m. Welcome and Logistics Tamar Schlekat
8:35 a.m.–8:40 a.m. Meeting Overview Natalia Vinas
Dan Villeneuve

Introduction to Environmental Risk Assessment and High-Throughput Screening
Session Chair: Natalia Vinas

8:40 a.m.–9:10 a.m. Fundamentals of Environmental Risk Assessment Jane Staveley
9:10 a.m.–9:40 a.m. A National Strategy to Modernize Safety Testing Nicole Kleinstreuer
9:40 a.m.–10:10 a.m. Accelerating the Development and Use of High-Throughput Screening Data for Application to Regulatory Risk Assessments Rusty Thomas
10:10 a.m.–10:40 a.m. Coffee Break
10:40 a.m.–11:10 a.m. HTPS In Vitro Human Cell-based Toxicity Screening of Compounds and Water Samples Peter Behnisch
11:10 a.m.–11:40 a.m. Looking for Data in All the (Sometimes) Right Places, from Experts to Machines and the Databases in Between Shannon Bell
11:40 a.m.–12:10 p.m. In Silico Approaches for Predicting Hazards from Chemical Structure and Existing Data Lyle Burgoon
12:10 p.m.–1:20 p.m. Lunch (on your own)

Challenges to the Use of Mechanistic and In Vitro Data in Environmental Risk Assessment – Emerging Solutions
Session Chair: Ellen Mihaich

1:20 p.m.–1:50 p.m. Historical and Perceived Limitations to the Use of Mechanistic Data in Environmental Risk Assessment Valery Forbes
1:50 p.m.–3:00 p.m. Diversity of Risk Assessment Context and Problems – Challenges Faced and Perspectives on the Potential Role for High-Throughput Screening Jane Staveley
Cheryl Murphy
Mark Jankowski
Daniel Chang
3:00 p.m.–3:30 p.m. Coffee Break
3:30 p.m.–3:50 p.m. Linking Mechanistic Data to Endpoints of Regulatory Concern Using the Adverse Outcome Pathway Framework Dan Villeneuve
3:50 p.m.–4:20 p.m. Translating In Vitro Effect Concentrations to In Vivo Dose and Environmental Exposure Concentrations Nynke Kramer
4:20 p.m.–4:45 p.m. Challenges in Extrapolating from Lab to Field and from Individuals to Populations and Ecosystems Valery Forbes

Story Problems
Session Chair: Ellen Mihaich

4:45 p.m.–5:30 p.m. The Practical Use of High-Throughput Data to Solve Real-World Risk Assessment Challenges: A Story Problem Approach Ellen Mihaich
Katie Coady
Beate Escher

Reception and Poster Social

5:30 p.m.–7:00 p.m. Poster Social

Data and Tools

Using the ToxCast and Tox21 Data
Session Chair: Dan Villeneuve

Time Title Speakers
8:30 a.m.–9:00 a.m. The USEPA Comptox Chemistry Dashboard: A Wed-based Data Integration Hub for Environmental Chemistry and Toxicology Data Antony Williams
9:00 a.m.–9:20 a.m. The ToxCast Data Pipeline: Purpose, Structure, On-Going Improvements and Example Katie Paul-Friedman
9:20 a.m.–9:40 a.m. Development and Distribution of Test Method Documentation for ToxCast High-Throughout Testing Assays Katie Paul-Friedman
Stacie Flood
9:40 a.m.–10:20 a.m. Understanding the Biology and Technology of ToxCast and Tox21 Assays Keith Houck
10:20 a.m.–10:50 a.m. Coffee Break
10:50 a.m.–11:15 a.m. In Vitro Chemical Screening Assays to Identify Thyroid Hormone Distruptors Michael Hornung
11:15 a.m.–11:35 a.m. Considerations for Developing and Implementing Performance-based Validation Approaches to Support ToxCast Assays Steven Levine

Intro to Complementary Tools
Session Chair: Cheryl Murphy

11:40 a.m.–12:00 p.m. Defining the Taxonomic Domain of Applicability for Mammalian-based High Throughput Screening Assays Dan Villeneuve
12:00 p.m.–12:15 p.m. Linking High-Throughput Screening Assay Responses to Potential Hazards and Adverse Effects – Adverse Outcome Pathway Knowledge Base Stephen Edwards
12:15 p.m.–12:30 p.m. Incorporating Sub-Organismal Processes that Occur at the Molecular and Cellular Level to Dynamic Energy Budgets to Determine Whole Organism Responses Cheryl Murphy

Lunch Networking

12:30 p.m.–2:30 p.m. Bring your lunch and join us for mingling with vendors, a genius bar and demonstrations of tools

Individual Chemical Assessments
Session Chair: Katie Coady

2:30 p.m.–2:55 p.m. What Needs to Be True? An Industry Perspective on Incorporating High-Throughput Screening Data in Environmental Risk Assessments Kristen Connors
2:55 p.m.–3:20 p.m. In Vitro Screening and Integrated Approaches for Testing and Assessment: An Industry Perspective Katie Coady
3:20 p.m.–3:50 p.m. Coffee Break
3:50 p.m.–4:15 p.m. Adverse-Outcome-Pathway–Informed Chemical Screening, Prioritization and Risk Assessment of Arthropod Endocrine Disruptors Knut Erik Tollefsen
4:15 p.m.–4:40 p.m. Case Study: High-Throughput Screening Applied to Hazard and Effects Assessment for Environmental Risk Assessment Dan Chang
4:40 p.m.–5:30 p.m. Brainstorming of Additional Applications, Research Needs and Questions and Follow-Up

Poster Social

5:30 p.m.–7:00 p.m. Poster Social

Application Case Studies – Environmental Monitoring and Complex Mixtures

High-Throughput Screening Data in Risk-Based Prioritization of Environmental Samples
Session Chair: Dan Villeneuve

Time Title Speakers
8:30 a.m.–9:00 a.m. Application of Exposure: Activity Rations from High-Throughput Screening to Evaluate Potential Biological Effects From Trace Organic Chemicals Steve Corsi
9:00 a.m.–9:20 a.m. Using High-Throughput Approaches to Assess Effectiveness of Wastewater and Stormwater Treatment
Dalma Martinovic-Weigelt
9:20 a.m.–9:45 a.m. Pilot Testing Cell-based Receptor Assays to Screen for Emerging Contaminants and Assess Risks in Aquatic Ecosystems Alvine Mehinto
9:45 a.m.–10:15 a.m. Coffee Break

Application of High-Throughput Screening Assays to Environmental Samples
Session Chair: Beate Escher

10:15 a.m.–10:45 a.m. EU SOLUTIONS Project – Application of High-Throughput Screening for Water Quality Monitoring and Effect-directed Analysis Henner Hollert
10:45 a.m.–11:10 a.m. Evaluation of In Vitro Bioactivity of Surface Waters from a Nationwide Assessment of United States Streams Brett Blackwell
11:10 a.m.–11:35 a.m. In Vitro Bioassays for Monitoring of Wastewater Treatment Effluent Inge Werner
11:35 a.m.–12:00 p.m. Mixture Toxicity Modeling to Link Chemical Concentrations to High-Throughput Screening Data of Environmental Samples and for Deriving Effects-based Trigger Values Beate Escher
12:00 p.m.–1:30 p.m. Lunch (on your own)

Story Problems
Session Chair: Natalia Vinas

1:30 p.m.–3:30 p.m. Discuss Story Problems and Revisit Brainstorming and Research Needs Ellen Mihaich
Katie Coady
Beate Escher
3:30 p.m.–4:00 p.m. Closing Dan Villeneuve
4:00 p.m. Meeting Adjourns