Meeting Program 2018-02-19T18:59:59+00:00

Preliminary Program

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High-Throughput Screening and Ecological Risk Assessment – Background and Setting the Stage

Time Title Format Speakers
7:45 a.m.–8:30 a.m. Registration
8:30 a.m.–8:40 a.m. Welcome and Logistics Plenary Presentation Tamar Schlekat, SETAC
8:40 a.m.–8:50 a.m. Meeting Overview Plenary Presentation Natalia Vinas, ERDC
Dan Villeneuve, USEPA

Introduction to Environmental Risk Assessment and High-Throughput Screening
Session Chair: Natalia Vinas

8:50 a.m.–9:20 a.m. Fundamentals of Environmental Risk Assessment Plenary Presentation Jane Staveley, Exponent
9:20 a.m.–9:45 a.m. Overall Challenge of Chemical Hazard Assessment and the Vision for TT21C Plenary Presentation Nicole Kleinstreuer, US NIEHS
9:45 a.m.–10:30 a.m. Overview of HTS Data Sources and Programs: ToxCast, Tox21, Seurat-EU ToxRisk and Other International HTS Initiatives Plenary Presentation Rusty Thomas, USEPA
10:30 a.m.–11:00 a.m. Coffee Break
11:00 a.m.–11:30 a.m. High-Throughput Mining of Extant Literature Sources of Bioactivity Bata via Automated Literature Mining and Existing Knowledge Bases Plenary Presentation Shannon Bell, US NIEHS Contractor
11:30 a.m.–12:10 p.m. In Silico Approaches for Predicting Hazards From Chemical Structure and Other Available Data Sources Plenary Presentation Lyle Burgoon, US Army
12:10 p.m.–1:20 p.m. Lunch (on your own)

Challenges to the Use of Mechanistic and In Vitro Data in Environmental Risk Assessment – Emerging Solutions
Session Chair: Ellen Mihaich

1:20 p.m.–1:50 p.m. Historical and Perceived Limitations to the Use of Mechanistic Data in ERA Plenary Presentation Valerie Forbes, University of Minnesota
1:50 p.m.–3:00 p.m. Diversity of Risk Assessment Context and Problems – Challenges Faced and Perspectives on the Potential Role for HTS Video and Panel Discussion Jane Staveley, Exponent
Mark Jankowski, USEPA
Daniel Chang, USEPA
3:00 p.m.–3:30 p.m. Coffee Break
3:30 p.m.–3:50 p.m. Linking Mechanistic Data to Endpoints of Regulatory Concern Using the AOP Framework Plenary Presentation Dan Villeneuve, USEPA
3:50 p.m.–4:20 p.m. Translating In Vitro Effect Concentrations to In Vivo Dose and Environmental Exposure Concentrations Plenary Presentation Nynke Kramer, Utrecht University
4:20 p.m.–4:45 p.m. Accounting for Adaptation and Resilience of Biological Systems and Ecosystems Plenary Presentation Valerie Forbes, University of Minnesota

Story Problems
Session Chair: Ellen Mihaich

4:45 p.m.–5:30 p.m. Introduction to Story Problems Plenary Presentation Ellen Mihaich, ER2
Katie Coady, Dow Chemical
Beate Escher, Helmholtz-Centre for Environmental Research – UfZ

Reception and Poster Social I

5:30 p.m.–7:00 p.m. Poster Social I, Reception and Exhibitors

Data and Tools

Using the ToxCast and Tox21 Data
Session Chair: Dan Villeneuve

Time Title Format Speakers
8:30 a.m.–9:00 a.m. Intro to the National Center For Computational Toxicology (NCCT) Chemistry Dashboard Demonstration Antony Williams, USEPA
9:00 a.m.–9:20 a.m. Differentiating Specific Pathway-based Activity From Non-specific Cytotoxicity Overview of the ToxCast Data Analysis Pipeline and Flags Plenary Presentation Katie Paul-Friedman, USEPA
9:20 a.m.–9:40 a.m. Performance-based Guidance and Assay Validation Plenary Presentation Steve Levine, Monsanto
9:40 a.m.–10:15 a.m. Understanding the Assays–Volume 1:
Apredica, Attagene, Novascreen, Odyessy Thera
and Cellzdirect
Plenary Presentation Keith Houck, USEPA
10:15 a.m.–10:45 a.m. Coffee Break
10:45 a.m.–11:15 a.m. Understanding the Assays–Volume 2:
Tox21, Bioseek, CEETOX, Zebrafish and Others
Plenary Presentation Stacie Flood, USEPA
Katie Paul-Friedman, USEPA
11:15 a.m.–11:35 a.m. Understanding the Assays–Volume 3:
Thyroid Axis-Related
Plenary Presentation Michael Hornung, USEPA

Intro to Complementary Tools
Session Chair: Cheryl Murphy

11:40 a.m.–12:00 p.m. Informing Cross Species Extrapolation: SeqAPASS Taxonomic Relevance of TC Targets Plenary Presentation Carlie LaLone, USEPA
12:00 p.m.–12:15 p.m. Linking HTS Assay Responses to Potential Hazards and Adverse Effects – AOP Knowledgebase Plenary Presentation Stephen Edwards, RTI
12:15 p.m.–12:30 p.m. Dynamic Energy Budget Modeling Plenary Presentation Cheryl Murphy, Michigan State University

Lunch Networking

12:30 p.m.–2:30 p.m. Bring your lunch and join us for mingling with exhibitors and vendors, a genius bar and demonstrations of tools such as:

  • iCSS Dashboard (Tony Williams, NCCT)
  • AOP-KB (Dan Villeneuve, USEPA)
  • SeqAPASS (Stephen Edwards, RTI)
  • ECOTOX (Carlie LaLone, USEPA)
  • EAR/ToxEval (Brett Blackwell, USEPA, and Steve Corsi, USGS)
  • DSS Tox
  • DEB Models
  • EcoSAR (Shannon Bell, National Institute of Environmental Health Sciences Contractor)
  • AOPXplorer (Lyle Burgoon, US Army)

Individual Chemical Assessments
Session Chair: Katie Coady

2:30 p.m.–2:55 p.m. Case Study: HTS Applied to Problem Formulation in Environmental Risk Assessment – Part I Plenary Presentation Katie Coady, Dow

2:55 p.m.–3:20 p.m. Case Study: HTS Applied to Problem Formulation in Environmental Risk Assessment – Part II Plenary Presentation Kristen Connors, P&G
3:20 p.m.–4:45 p.m. Case Study: HTS Applied to Hazard and Effects Assessment for Environmental Risk Assessment Plenary Presentation Dan Chang, USEPA
4:45 p.m.–5:10 p.m. Case Study: HTS Applied to Criteria and Standards Development (e.g., AWQC) Plenary Presentation Knut Erik Tollefso, Norwegian University of Life Sciences
5:10 p.m.–5:30 p.m. Additional Applications, Research Needs, and Questions and Answers Plenary Discussion Katie Coady, Dow Chemical

Poster Social II

5:30 p.m.–7:00 p.m. Poster Social II

Application Case Studies – Environmental Monitoring and Complex Mixtures

HTS Data in Risk-Based Prioritization of Environmental Samples
Session Chair: Dan Villeneuve

Time Title Format Speakers
8:30 a.m.–9:00 a.m. Case Study: Risk-based Prioritization of Sites and Chemicals Using Exposure:Activity Ratios – Part I Plenary Presentation Steve Corsi, USGS
9:00 a.m.–9:20 a.m. TBA TBA TBA
9:20 a.m.–9:45 a.m. Case Study  Plenary Presentation Alvine Mehinto, Southern California Coastal Water Research Project
9:45 a.m.–10:15 a.m. Coffee Break

Application of HTS Assays to Environmental Samples
Session Chair: Beate Escher

10:15 a.m.–10:45 a.m. EU SOLUTIONS Project – Application of HTS for Water Quality Monitoring and Effect-directed Analysis Plenary Presentation Henner Hollert, RWTH Aachen
10:45 a.m.–11:05 a.m. Attagene Battery of ToxCast Assays for Analysis of Environmental Samples Plenary Presentation Brett Blackwell, USEPA
11:05 a.m.–11:30 a.m. In Vitro and HTS Tools for Water Quality Monitoring and Assessment of Sewage Treatment Processes Plenary Presentation Inge Werner, Swiss Ecotox Centre
11:30 a.m.–12:00 p.m. Mixture Toxicity Modeling to Link Analytical Concentrations and HTS Effect Data to Observed Effects of Environmental Samples and Deriving Effects-based Trigger Values Plenary Presentation Beate Escher, Helmholtz-Centre for Environmental Research – UfZ
12:00 p.m.–2:00 p.m. Lunch (on your own)

Story Problems
Session Chair: Natalia Vinas

2:00 p.m.–4:30 p.m. Discuss Story Problems and Revisit Brainstorming and Research Needs Facilitated Plenary Discussion Ellen Mihaich, ER2
Katie Coady, Dow Chemical
Beate Escher, Helmholtz-Centre for Environmental Research – UfZ
4:30 p.m.–5:15 p.m. Closing Dan Villeneuve, USEPA
5:15 p.m. Meeting Adjourns
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